Synthesis and Antimicrobial Evaluation of some novel Schiff bases derived from Benzothiazole derivative

In an attempt to find out a new class of antimicrobial agents new series of Benzylidine-2imino-1,3-benzothiazole and other related products containing benzothiazole moiety were prepared. The synthesis was carried out by condensation of different aromatic aldehydes with benzothiazole derivative using different procedures. The synthesised compounds were characterized and evaluated for antimicrobial activities. The newly synthesized compounds were tested against representatives of gram-positive and gramnegative bacteria ( staphylococcus aureus and Basillus subtilis. ) by agar diffusion method using Ampicillin as control. The result indicates that the compounds possessed a broad spectrum of activity against the tested microorganisms. Structures of the newly synthesized compounds were established by physical and spectroscopic analysis.